FOSCARNET PACKAGE INSERT PDF

Name of the medicinal product. Foscavir 24 mg/ml Solution for Infusion. 2. Qualitative and quantitative composition. Foscarnet trisodium hexahydrate 24 mg /ml. Package leaflet: Information for the user. Foscavir®. 24 mg/ml Solution for Infusion foscarnet. M UK. Read all of this leaflet carefully before you start. Foscavir™ (Foscarnet Sodium) Injection Product Insert rubber latex has not been used in the manufacture of this device or drug container closure system.

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Vandetanib can prolong the QT interval in a concentration-dependent manner.

When possible, avoid concomitant administration of systemic bacitracin and other nephrotoxic drugs such as foscarnet. Major When possible, avoid concurrent use of foscarnet with other drugs known to prolong the QT interval, such as triptorelin. Serum creatinine concentrations and urine output should be closely monitored during and subsequent to this period. When diuretics are indicated, thiazides are recommended.

QT prolongation has also occurred during therapeutic use of aripiprazole and following overdose. Pazopanib has also been reported to prolong the QT interval. Moderate The manufacturer recommends using aprotinin cautiously in patients that are receiving drugs that can affect renal function, such as foscarnet, as the risk of renal impairment may be increased.

Sufficient washout foxcarnet of drugs that are known to prolong the QT interval prior to administration of macimorelin is recommended. Major When possible, avoid concurrent use of foscarnet with other drugs known to prolong the QT interval, such as leuprolide. Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate: Major Systemic polymyxin B should not be used concurrently or sequentially with other drugs that have the potential for nephrotoxicity or neurotoxicity such as foscarnet.

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In addition, reduced kidney function secondary to Aldesleukin treatment may delay elimination of concomitant medications and increase the risk of adverse events from those drugs.

Major When possible, avoid concurrent use of foscarnet with other drugs known to prolong the QT interval, such as maprotiline. Monitor renal function before and during telbivudine treatment.

Monitor renal function carefully during concurrent therapy. Major Avoid coadministration of foscarnet with toremifene due to the risk of additive QT prolongation. Solifenacin has been associated with dose-dependent prolongation of the QT interval.

Foscavir (foscarnet sodium) dose, indications, adverse effects, interactions from

Major When possible, avoid concurrent use of foscarnet with other drugs known to prolong the QT interval, such as metronidazole. Major When possible, avoid concurrent use of foscarnet with other drugs known to prolong the QT interval, such as moxifloxacin. Major When possible, avoid concurrent use of foscarnet with other drugs known to prolong the QT interval, such as eliglustat.

Tolterodine has been associated with dose-dependent prolongation of the QT interval, especially in poor CYP2D6 metabolizers.

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Therefore, patients must be carefully monitored for such electrolyte imbalances and potential sequelae. In patients with normal renal function, the distribution and elimination half-lives are 0. To email a medicine you must sign up and log in.

Major When possible, avoid concurrent use of foscarnet with other drugs known to prolong the QT interval, such as lithium. Treatment should be discontinued in those whose CrCl drops foscarneh 0.

Fluconazole has also been associated with QT prolongation and rare cases of TdP. This occurs through prevention of pyrophosphate cleavage from deoxynucleoside triphosphate and elongation of the viral DNA chain. Foscarnet is only indicated for use in immunocompromised patients with CMV retinitis and mucocutaneous acyclovir-resistant HSV infections.

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Ribociclib has been shown to prolong the Ibsert interval in a concentration-dependent manner. Talimogene laherparepvec is a live, attenuated herpes simplex virus that is sensitive to acyclovir; coadministration with antiviral agents may cause a decrease in efficacy.

Major When possible, avoid concurrent use of foscarnet with other drugs known to prolong the QT interval, such as loperamide. Vardenafil is inserh associated with QT prolongation. There have also been case reports of QT prolongation and TdP with postmarketing use of azithromycin. An observed reduction of serum electrolytes such as calcium and magnesium can be explained by the property of foscarnet to form chelate with divalent metal insett.

Induction therapy of mucocutaneous HSV infections unresponsive to aciclovir: Please refer to sections 4. Itraconazole has also been associated with prolongation of the QT interval. Bictegravir; Emtricitabine; Tenofovir Alafenamide: Muscular weakness, myopathy, myositis, rhabdomyolysis.

To view the changes to a medicine you must sign up and log in. Major The risk of renal toxicity may be increased if foscarnet is used in conjunction with other nephrotoxic agents such as cisplatin. Closely monitor renal function and adjust telavancin doses based on calculated creatinine clearance. Autoradiographic studies showed that foscarnet has a pronounced affinity to bone tissue. Dilute under aseptic conditions. The electrolytes, especially calcium and magnesium, should be assessed prior to and during Foscavir therapy and deficiencies corrected.

Moderate Aldesleukin may cause nephrotoxicity.